The Management Handbook structures the collaboration of the consortium, the Scientific Lead (SL) and the Project Coordinator (PC) in the project InvigoratEU. First, it gives an overview of the general information of the project and the important dates during the project. It informs about the rules and procedures for meetings, such as the General Assembly and the three main conferences. Since reporting is of high importance in the project, the legal points as well as the InvigoratEU specific procedures are described here. Regarding the budget, the budget flexibility as well as amendments, the relevant points from the grant agreement are summarized and complemented by the concrete procedures of InvigoratEU. The handbook contains information on data management, which will be expanded by the data management plan. As the dissemination of the project's results is highly relevant, the manual contains information on publications and the acknowledgement of EU funding/disclaimer. To ensure the success of the project, a quality assurance, risk assessment and contingency plan was prepared. Moreover, information is provided on the digital infrastructure set up by the Coordinator. In addition to the information, the manual contains practical advice on project procedures and communication to ensure efficient cooperation.