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University of Duisburg-Essen

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170 Projects, page 1 of 34
  • Funder: European Commission Project Code: 706672
    Overall Budget: 159,461 EURFunder Contribution: 159,461 EUR

    This project, "Interfaces in Turbulent Premixed Flames" (ITPF), aims at improving the physical understanding of the entrainment of hot products in annular co-flows of turbulent premixed flames into jets of fresh reactants. This research will characterize the entrainment processes through the study and comparison of Turbulent/Non-Turbulent (T/NT) and scalar interfaces in turbulent premixed flames. This is an essential point in combusting turbulent free shear flows, because a better knowledge of the dynamics of T/NT and scalar interfaces would lead to better predictions of flame instabilities and field structures. Moreover, the insight gained by this analysis will, in turn, be used to propose more physically sound and accurate turbulent mixing models. The entrainment mechanisms have been studied for the past decades. However, the description and quantification of the importance of small and large scales contributing to it is still unsolved. Thus, this research will use methodologies to locally characterize small-scale scalar structures and flow topologies, as well as, to scrutinize how large and medium size vortices influence and drive the entrainment processes. Therefore, this research requires high resolution simulations to investigate the structure of the enstrophy and scalar interfaces; this proposal intends to develop a Direct Numerical Simulation (DNS) of a turbulent premixed flame and analyze its results, in conjunction with Large Eddy Simulations (LES). A smart combination of DNS and LES will permit to unveil contributions of large and small structures to the entrainment process, to better comprehend physical mechanisms and to formulate sound and accurate mixing and combustion models. In summary, this proposal will directly address the cross-cutting priority of sustainable development in Information Science and Engineering established by the H2020 Work Programme and will reinforce the already large European competitiveness in turbulent combustion research.

  • Funder: European Commission Project Code: 842487
    Overall Budget: 264,669 EURFunder Contribution: 264,669 EUR

    Deaf learners have been highly neglected in mathematics education research so far. Although numerous studies in the field of deaf education have pointed out deaf students’ problems in learning mathematics and highlight a lack of mathematical skills, empirical research mainly took a deficit-oriented perspective on deaf students' learning instead of trying to better understand the specificity of their learning processes. One aspect shaping their particular way of learning mathematics is their use of spatio-motoric sign language, not only seeing it as a visual means of expression, but also as an embodied way to encounter and communicate mathematical ideas. Building on theoretical insights from my prestudy on the influence of sign language in mathematical conceptualization, this project aims at adding a more practical side to my research program on better aligning math education to deaf students’ ways of doing math. The project combines the two objectives of - designing and developing a learning environment that builds on specific resources and strengths of deaf learners—in particular their use of sign language—in order to realise their mathematical potential, and, - extending the existing knowledge on learning processes and the role of the body therein. This will be realized within a Design Based Research approach, in which development of educational material and of theory go hand in hand while passing several cycles of testing and refinement. In particular, the design is aligned to an embodied approach, assuming that (inter)acting and thinking are deeply entwined in such a way that mathematical thinking develops in activity and, at the same time, becomes expressed in it. The Embodied Design Research Laboratory at UC Berkeley provides excellent conditions to carry out this project while adding a new perspective to the work of the lab. The benefit of the educational learning design for other, linguistically diverse, settings will be explored in the return phase.

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  • Funder: European Commission Project Code: 658992
    Overall Budget: 159,461 EURFunder Contribution: 159,461 EUR

    Early cancer diagnosis greatly increases the chances for successful treatment and personalised therapy. RNA molecules have emerged as new candidate biomarkers for detecting a wide variety of cancers, due to their critical role in cell growth and development. In situ hybridization techniques for mRNA detection provide detailed spatial and temporal information on RNA expression with single-molecule sensitivity, however the traditional techniques that utilise fluorescence probes and quantum dots lack of high multiplexing capabilities. RISH seeks to develop a methodology that allows sensitive multiplex detection, quantification and distribution of cellular mRNA biomarkers utilising surface-enhanced Raman spectroscopy (SERS) nanoparticle (NP) labels. SERS NP-labels consist of metal nanoparticles modified with a self-assembled monolayer of Raman reporters and are sensitive and robust labels that offer great multiplexing capacity. Molecular beacon hybridization probes specific to mRNA targets will be conjugated to SERS NP-labels to allow optical detection utilising Raman microscopy in human cancer tissue sections. The mRNA expression levels will be correlated with those from fluorescence in situ hybridization and the respective protein expression levels after immunohistochemistry. The research proposal is highly multidisciplinary and includes aspects of spectroscopy, optics, biochemistry, nanotechnology and pathology. The research fellow plans to work closely with experts from both the hospital and the industry to apply this methodology in the diagnosis of initially breast cancer and of different types of cancer at a later stage.

  • Funder: European Commission Project Code: 236127
  • Funder: European Commission Project Code: 832833
    Overall Budget: 2,124,660 EURFunder Contribution: 2,124,660 EUR

    Enumerative geometry, the mathematics of counting numbers of solutions to geometric problems, and its modern descendents, Gromov-Witten theory, Donaldson-Thomas theory, quantum cohomology and many other related fields, analyze geometric problems by computing numerical invariants, such as intersection numbers or degrees of characteristic classes. This essentially algebraic approach has been successful mainly in the study of problems over the complex numbers and other algebraically closed fields. There has been progress in attacking enumerative problems over the real numbers; the methods are mainly non-algebraic. Arithmetic content underlying the numerical invariants is hidden when analyzed by these non-algebraic methods. Recent work by the PI and others has opened the door to a new, purely algebraic approach to enumerative geometry that recovers results in both the complex and real cases in one package and reveals this arithmetic content over arbitrary fields. Building on these new developments, the goals of this proposal are, firstly, to use motivic homotopy theory, algebraic geometry and symplectic geometry to develop new purely algebraic methods for handling enumerative problems over an arbitrary field, secondly, to apply these methods to central enumerative problems, recovering and unifying known results over both C and R and thirdly, to use this new approach to reveal the hidden arithmetic nature of enumerative problems. In 2009 R. Pandharipande and I applied algebraic cobordism to prove the degree zero MNOP conjecture in Donaldson-Thomas theory. More recently, I have developed several aspects of the theory of quadratic invariants using motivic homotopy theory.


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