In the current phase of an ongoing study, we systematically investigate the effects of porenetwork geometry and wettability on two-phase flow in porous media. The aim is to address the problemof end-effects in SCAL measurements. Systematic, steady-state, co-injection experiments are conducted inplanar, transparent microfluidic networks: a periodic and a non-periodic network made of PDMS, and aperiodic network made of glass. This setup enables isolation and comparison of the effects of networkgeometry and wettability for a broad domain of flow conditions spanning 3 orders of magnitude of thecapillary number and the flowrate ratio. Taking ex-core measurements of pressure drops, we extract thedependence of the relative permeabilities and the intrinsic dynamic capillary pressure on the flowrates, foreach examined system. We have developed a specialized imaging algorithm to monitor the spatiotemporalevolution of statistical properties of the interstitial flow in steady-state and transients (flowrate bumpincrements). We also evaluate the establishment of fully-developed interstitial flow and we correlate it tothe interstitial flow structure and the magnitude of end-effects. The work provides mechanistic insightsthat have a potential for improving SCAL protocols. The ultimate aim is to generate flow-dependentrelative permeability maps that are true to the underlying physics, thereby enhancing the specificity,reliability, and predictive accuracy of reservoir simulation models.