Presentation from Open Science: Monitoring Progress, Assessing Impact conference held 7–8 July 2025 at UNESCO Headquarters in Paris and online. Annotation: This session introduces two key tools developed through PathOS: the Open Science Impact Indicator Handbook and a framework for assessing the value of open science practices. The Handbook provides a structured set of indicators to monitor academic, societal, and economic impacts. The Cost-Benefit Analysis framework shows how selected indicators can support strategic decision-making by estimating potential benefits beyond just monetary measures. Following the presentations, the session continues with a panel discussion on practical challenges, insights, and opportunities in applying these tools. Learn more about the conference and check out other presentations here: https://pathos-project.eu/conference-on-open-science-monitoring-progress-assessing-impact