Deliverable 1.1 provides a detailed outline covering the theoretical framework and methodology for a human-centred approach. It ensures that all relevant stakeholders are involved throughout the project phases, emphasising a mixed methods approach, specifically the exploratory sequential design. Additionally, it presents an evaluation plan for all project phases, including user requirement gathering, usability and UX testing, presence evaluation, and system Ethics, Trust, and Privacy evaluation, detailing stakeholder involvement. The deliverable also includes detailed use case descriptions and scenarios for Professional Collaboration, Manufacturing Training, Health, and Cultural Heritage. These scenarios translate use case descriptions from a user perspective and are discussed in D5.1 Integration and Demonstration I - Initial definition and planning as well. Furthermore, preliminary results on the robustness and reliability of artificial intelligence (AI) within PRESENCE are presented, along with a register of AI components to be developed, which will be regularly updated. Moreover, an overview of the initial set of User Requirements is presented, which is based on the Use Case descriptions from the proposal, the Use Case descriptions discussed at the project kick-off meeting, and insights from co-creation workshops with consortium members. These initial requirements mark the first step in iteration. Finally, the deliverable proposes a strategic recruitment plan, incorporating the walk-through method and Guidance Ethics approach from task 1.5 including an overall recruitment strategy, a call for participation, and informed consent. The deliverable concludes by considering the next steps, given its iterative nature.