Open innovation has become a key strategy to successfully overcome the new challenges that pharmaceutical companies are facing today.? Sanofi has created an Open Innovation R&D Centre in Strasbourg dedicated to early research phase with the aim to accelerate thediscovery of innovative targets and lead compounds. With a privileged strategic situation in Biovalley, this Centre makes the best of science,talents and resources to leverage external innovation from upper Rhine Valley Ecosystem and beyond.? The Centre integrates internal and external healthcare research collaborations in facilitating network and synergies.? The projects, sponsored by Therapeutic Areas, contribute to the renewal of Sanofi R&D portfolio and offer our academic partners theopportunity to move their basic research discoveries towards clinical application.