Harmonized code Trait Description PGP1 FA2 The percentage of FA2 PGP2 FA2B The percentage of FA2B PGP3 A2BG1 The percentage of A2BG1 PGP4 FA2G1 The percentage of FA2G1 PGP5 FA2G1 The percentage of FA2G1 PGP6 FA2BG1 The percentage of FA2BG1 PGP7 M6 The percentage of M6 PGP8 A2G2 The percentage of A2G2 PGP9 A2BG2 The percentage of A2BG2 PGP10 FA2G2 The percentage of FA2G2 PGP11 FA2BG2 The percentage of FA2BG2 PGP12 M7 + A2G2S1 The percentage of M7+A2G2S1 PGP13 FA2G1S1 The percentage of FA2G1S1 PGP14 A2G2S1 The percentage of A2G2S1+A2G2S1 PGP15 FA2G2S1 The percentage of FA2G2S1 PGP16 FA2BG2S1 The percentage of FA2BG2S1 PGP17 A2G2S2 The percentage of A2G2S2 PGP18 M9 The percentage of M9 PGP19 A2G2S2 The percentage of A2G2S2 PGP20 FA2G2S2 The percentage of FA2G2S2 PGP21 FA2BG2S2 The percentage of FA2BG2S2 PGP22 A3G3S2 The percentage of A3G3S2 PGP23 A3G3S2 The percentage of A3G3S2 PGP24 A3F1G3S2 The percentage of A3F1G3S2 PGP25 A3G3S3 The percentage of A3G3S3 PGP26 A3G3S3 The percentage of A3G3S3 PGP27 A3G3S3 The percentage of A3G3S3 PGP28 FA3G3S3 The percentage of FA3G3S3 PGP29 A3G3S3 The percentage of A3G3S3 PGP30 A3F1G3S3 The percentage of A3F1G3S3 PGP31 FA3G3S3 The percentage of FA3G3S3 PGP32 FA3F1G3S3 The percentage of FA3F1G3S3 PGP33 A4G4S3 The percentage of A4G4S3 PGP34 A4G4S4 The percentage of A4G4S4 PGP35 A4G4S4 The percentage of A4G4S4 PGP36 A4F1G4S4 The percentage of A4F1G4S4 PGP37 FGS/(FG+FGS) The percentage of sialylation of core-fucosylated galactosylated structures without bisecting GlcNAc PGP38 FBGS/(FBG+FBGS) The percentage of sialylation of core-fucosylated galactosylated structures with bisecting GlcNAc PGP39 FGS/(F+FG+FGS) The percentage of sialylation of all core-fucosylated structures without bisecting GlcNAc PGP40 FBGS/(FB+FBG+FBGS) The percentage of sialylation of all core-fucosylated structures with bisecting GlcNAc PGP41 FG1S1/(FG1+FG1S1) The percentage of monosialylation of core-fucosylated monogalactosylated structures without bisecting GlcNAc PGP42 FG2S1/(FG2+FG2S1+FG2S2) The percentage of monosialylation of core-fucosylated digalactosylated structures without bisecting GlcNAc PGP43 FG2S2/(FG2+FG2S1+FG2S2) The percentage of disialylation of core-fucosylated digalactosylated structures without bisecting GlcNAc PGP44 FBG2S1/(FBG2+FBG2S1+FBG2S2) The percentage of monosialylation of core-fucosylated digalactosylated structures with bisecting GlcNAc PGP45 FBG2S2/(FBG2+FBG2S1+FBG2S2) The percentage of disialylation of core-fucosylated digalactosylated structures with bisecting GlcNAc PGP46 FtotalS1/FtotalS2 Ratio of all fucosylated monosialylated and disialylated structures (+/- bisecting GlcNAc) PGP47 FS1/FS2 Ratio of fucosylated monosialylated and disialylated structures (without bisecting GlcNAc) PGP48 FBS1/FBS2 Ratio of fucosylated monosialylated and disialylated structures (with bisecting GlcNAc) PGP49 FtotalS1/FtotalS3 Ratio of all core-fucosylated monosialylated and trisialylated structures (+/- bisecting GlcNAc) PGP50 FS1/FS3 Ratio of core-fucosylated monosialylated and trisialylated structures (without bisecting GlcNAc) PGP51 FtotalS2/FtotalS3 Ratio of all core-fucosylated disialylated and trisialylated structures (+/- bisecting GlcNAc) PGP52 FS2/FS3 Ratio of core-fucosylated disialylated and trisialylated structures (without bisecting GlcNAc) PGP53 FBStotal/FStotal Ratio of all core-fucosylated sialylated structures with and without bisecting GlcNAc PGP54 FBS1/FS1 Ratio of fucosylated monosialylated structures with and without bisecting GlcNAc PGP55 FBS1/(FS1+FBS1) The incidence of bisecting GlcNAc in all fucosylated monosialylated structures PGP56 FBS2/FS2 Ratio of fucosylated disialylated structures with and without bisecting GlcNAc PGP57 FBS2/(FS2+FBS2) The incidence of bisecting GlcNAc in all fucosylated disialylated structures PGP58 FA2n The percentage of FA2 in total neutral plasma glycans (GPn) PGP59 FA2Bn The percentage of FA2B in total neutral plasma glycans (GPn) PGP60 A2BG1n The percentage of A2BG1 in total neutral plasma glycans (GPn) PGP61 FA2G1n The percentage of FA2G1 in total neutral plasma glycans (GPn) PGP62 FA2G1n The percentage of FA2G1 in total neutral plasma glycans (GPn) PGP63 FA2BG1n The percentage of FA2BG1 in total neutral plasma glycans (GPn) PGP64 M6n The percentage of M6 in total neutral plasma glycans (GPn) PGP65 A2G2n The percentage of A2G2 in total neutral plasma glycans (GPn) PGP66 A2BG2n The percentage of A2BG2 in total neutral plasma glycans (GPn) PGP67 FA2G2n The percentage of FA2G2 in total neutral plasma glycans (GPn) PGP68 FA2BG2n The percentage of FA2BG2 in total neutral plasma glycans (GPn) PGP69 M9n The percentage of M9 in total neutral plasma glycans (GPn) PGP70 G0n The percentage of agalactosylated structures in total neutral plasma glycans PGP71 G1n The percentage of monogalactosylated structures in total neutral plasma glycans PGP72 G2n The percentage of digalactosylated structures in total neutral plasma glycans PGP73 Fn total The percentage of all fucosylated structures (+/- bisecting GlcNAc) in total neutral plasma glycans PGP74 FG1n total/G1n The percentage of fucosylation of monogalactosylated structures in total neutral plasma glycans PGP75 FG2n total /G2n The percentage of fucosylation of digalactosylated structures in total neutral plasma glycans PGP76 Fn The percentage of fucosylated structures (without bisecting GlcNAc) in total neutral plasma glycans PGP77 FG0n/G0n The percentage of fucosylation of agalactosylated structures (without bisecting GlcNAc) in total neutral plasma glycans PGP78 FG1n/G1n The percentage of fucosylation of monogalactosylated structures (without bisecting GlcNAc) in total neutral plasma glycans PGP79 FG2n/G2n The percentage of fucosylation of digalactosylated structures (without bisecting GlcNAc) in total neutral plasma glycans PGP80 FBn The percentage of fucosylated structures (with bisecting GlcNAc) in total neutral plasma glycans PGP81 FBG0n/G0n The percentage of fucosylation of agalactosylated structures (with bisecting GlcNAc) in total neutral plasma glycans PGP82 FBG1n/G1n The percentage of fucosylation of monogalactosylated structures (with bisecting GlcNAc) in total neutral plasma glycans PGP83 FBG2n/G2n The percentage of fucosylation of digalactosylated structures (with bisecting GlcNAc) in total neutral plasma glycans PGP84 FBn/Fn Ratio of fucosylated structures with and without bisecting GlcNAc in total neutral plasma glycans PGP85 FBn/Fn total The incidence of bisecting GlcNAc in all fucosylated structures in total neutral plasma glycans PGP86 Fn/(Bn+FBn) Ratio of fucosylated non-bisecting GlcNAc structures and all structures with bisecting GlcNAc in total neutral plasma glycans PGP87 Bn/(Fn+FBn) Ratio of afucosylated structures with bisecting GlcNAc and all fucosylated structures (+/- bisecting GlcNAc) in total neutral plasma glycans PGP88 FBG2n/FG2n Ratio of fucosylated digalactosylated structures with and without bisecting GlcNAc in total neutral plasma glycans PGP89 FBG2n /(FG2n+FBG2n ) The incidence of bisecting GlcNAc in all fucosylated digalactosylated structures in total neutral plasma glycans PGP90 FG2n/(BG2n+FBG2n) Ratio of fucosylated digalactosylated non-bisecting GlcNAc structures and all digalactosylated structures with bisecting GlcNAc in total neutral plasma glycans PGP91 BG2n/(FG2n+FBG2n) Ratio of afucosylated digalactosylated structures with bisecting GlcNAc and all fucosylated digalactosylated structures (+/- bisecting GlcNAc) in total neutral plasma glycans PGP92 FUC-A The percentage of antennary fucosylated structures in total plasma glycans PGP93 FUC-C The percentage of core fucosylated structures in total plasma glycans PGP94 S0total The percentage of neutral glycan structures in total plasma glycans PGP95 S1total the percentage of monosialylated structures in total plasma glycans PGP96 S2total the percentage of bisialylated structures in total plasma glycans PGP97 S3total the percentage of trisialylated structures in total plasma glycans PGP98 S4total the percentage of tetrasialylated structures in total plasma glycans PGP99 G0total The percentage of agalactosylated structures in total plasma glycans PGP100 G1total The percentage of monogalactosylated structures in total plasma glycans PGP101 G2total The percentage of digalactosylated structures in total plasma glycans PGP102 G3total The percentage of trigalactosylated structures in total plasma glycans PGP103 G4total The percentage of tetragalactosylated structures in total plasma glycans PGP104 A2total The percentage of biantennary structures in total plasma glycans PGP105 A3total The percentage of triantennary structures in total plasma glycans PGP106 A4total The percentage of tetraantennary structures in total plasma glycans PGP107 Mtotal The percentage of high-mannose structures in total plasma glycans PGP108 Btotal The percentage of glycan structures with bisecting GlcNAc in total plasma glycans PGP109 G3S2/G3S3 Ratio of disialylated and trisialylated trigalactosylated structures PGP110 G4S3/G4S4 Ratio of trisialylated and tetrasialylated tetragalactosylated structures PGP111 FG3/G3total The percentage of core-fucosylation of trigalactosylated structures PGP112 G3Fa/G3total The percentage of antennary-fucosylation of trigalactosylated structures PGP113 G4Fa/G4total The percentage of antennary-fucosylation of tetragalactosylated structures PGP114 M7n The percentage of M7 in total neutral plasma glycans (GPn) PGP115 Stotal The percentage of sialylated structures in total plasma glycans PGP116 Gtotal The percentage of galactosylated structures in total plasma glycans PGP117 Gntotal The percentage of galactosylated structures in total neutral plasma glycans

The dataset contains results of genome-wide association study of human blood plasma glycome. The TPNG_GWAMA_eur_10k.tar.gz contains summary statistics for 117 glycome traits from the European GWAMA (Genome-Wide Association Meta-Analysis) conducted on participants of European ancestry, totaling 10,172 individuals. The 117 files contain association summary statistics for 117 glycome traits, of which 36 were directly measured by UHPLC technology and 81 were derived glycome traits. Funding The work of S.Sh., A.T., D.M., A.S., Y.S.A. was supported by the Research Program at the Moscow State University (MSU) Institute for Artificial Intelligence. The study was conducted using the UK Biobank resource under application #59345. The work of E.E., Y.A.T was supported by the budget project of the Institute of Cytology and Genetics FWNR-2022-0020. European Community’s Seventh Framework Programme funded project PainOmics (602736). TwinsUK is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), Zoe Ltd and the National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. The TwinsUK Study was approved by London-Westminster Research Ethics Committee (REC reference EC04/015), and Guy’s and St Thomas’ NHS Foundation Trust Research and Development (R&D). The TwinsUK BioBank was approved by the HRA - Liverpool East Research Ethics Committee (REC reference 19/NW/0187), IRAS ID 258513. Glycan analysis performed in Genos was supported by Horizon Europe grants GlycanSwitch (ERC Synergy grant # 101071386), INITIALISE (grant # 101094099) and SynHealth (grant #101159018). All participants provide written, informed consent. We thank Toma Keser, Mirna Šimurina, Marija Vilaj, Jerko Štambuk, Ivan Gudelj, Thomas S. Klarić, Jasminka Krištić, Jelena Šimunović, Julija Jurić, Ana Momčilović, Najda Rudman, and Maja Hanić for their assistance with glycan analysis. Headers rs_id - dbSNP ID. chr - Chromosome number where the SNP is located. bp - Base pair position of the SNP on the chromosome (build GRCh37/hg19). ea - Effect allele. ra - Reference allele. eaf - Effect allele frequency. af_ref - Frequency of the reference allele. beta - Effect size estimate. se - Standard error of the effect size estimate. p - P-value for the association test. n - Sample size used in the analysis. z - Z-score for the association test. info - Imputation information score.