This article examines the comparative typology of sentence structures in English and Uzbek, focusing on the syntactic and morphological differences between these languages. English, a Germanic, analytic language, heavily relies on word order and auxiliary verbs to express grammatical relationships, while Uzbek, a Turkic, agglutinative language, utilizes a complex system of affixes and word-order flexibility. By comparing simple, compound, and complex sentences, this paper highlights the linguistic structures of both languages. The study reveals how typological features such as inflection, word order, and syntactic markers contribute to differences in sentence formation, providing insights into language learning, translation, and computational linguistics.