To avoid settling of molten materials directly on the vessel wall in severe accident sequences, the implementation of a ‘core catcher’ device in the lower plenum of sodium fast reactor designs is considered. The device is to collect, retain and cool the debris, created when the corium falls down and accumulates in the core catcher, while interacting with surrounding coolant. This Fuel-Coolant Interaction (FCI) leads to a potentially energetic heat and mass transfer process which may threaten the vessel integrity. For simulations of severe accidents, including FCI, the SIMMER code family is employed at KIT. SIMMER-III and SIMMER-IV are advanced tools for the core disruptive accidents (CDA) analysis of liquid-metal fast reactors (LMFRs) and other GEN-IV systems. They are 2D/3D multi-velocity-field, multiphase, multicomponent, Eulerian, fluid dynamics codes coupled with a fuel-pin model and a space- and energy-dependent neutron kinetics model. However, the experience of SIMMER application to simulation of corium relocation and related FCI is limited. It should be mentioned that the SIMMER code was not firstly developed for the FCI simulation. However, the related models show its basic capability in such complicate multiphase phenomena. The objective of the study was to preliminarily apply this code in a large-scale simulation. An in-vessel model based on European Sodium Fast Reactor (ESFR) was established and calculated by the SIMMER code. In addition, a sensitivity analysis on some modeling parameters is also conducted to examine their impacts. The characteristics of the debris in the core catcher region, such as debris mass and composition are compared. Besides that, the pressure history in this region, the mass of generated sodium vapor and average temperature of liquid sodium, which can be considered as FCI quantitative parameters, are also discussed. It is expected that the present study can provide some numerical experience of the SIMMER code in plant-scale corium relocation and related FCI simulation.