Achieving climate neutrality in aviation necessitates the development of innovative technologies and operational strategies. The INDIGO project, funded under the Horizon Europe programme, introduces a novel mid-range aircraft featuring distributed hybrid electric propulsion (DHEP) and Large Aspect-Ratio Wings (LARW). To accurately evaluate trade-off solutions, a multidisciplinary optimization framework was developed. This framework incorporates advanced design and simulation tools to balance aerodynamic performance, fuel efficiency, and emissions reduction. The introduction of LARW-DHEP shows potential for significant emissions reductions, particularly during climb and landing operations. The INDIGO project approach highlights the feasibility and benefits of integrating DHEP and LARW in future aircraft designs, demonstrating the importance of holistic optimization in achieving sustainable aviation goals.