Context: The municipality of Yaounde faces serious waste management issues, affecting approximately 500,000 inhabitants spread across some 100,000 households. Challenges include irregular collection, lack of adequate infrastructure, and the presence of illegal dumps polluting the environment. Methods: The project, conducted by "EcoClean Environnement" from 2016 to 2020, aimed to evaluate the health, environmental, and economic impact of waste pre-collection in the Urban Community of Yaoundé III and to demonstrate the importance of the circular economy for sustainable resource management. It involved all households in the district, local businesses, and trained agents for pre-collection. Awareness campaigns and collection points were established, along with sorting and recycling centers to valorize waste. Results: The project demonstrated a significant reduction (44.44%, p < 0.01) in uncollected waste and a 60% improvement (p < 0.01) in the cleanliness of green spaces and waterways. It also notably reduced (p < 0.05) diseases associated with poor waste management and the proliferation of disease vectors. The project created 200 jobs (p < 0.01) and stimulated the development of 10 new local businesses specializing in waste management. Conclusion: The project transformed waste management in Yaoundé III, improving the quality of life, reducing environmental impacts, and stimulating local economic development, supported by robust statistical results.