Background: The present Randomized Controlled Trial (RCT) was conducted in the Postgraduate Department of Anatomy, Government Medical College Srinagar after taking ethical clearance from Institutional Ethical Committee. Materials and Methods: Fourteen albino rats weighing on an average 150 grams were taken from the animal house of Govt. Medical College Srinagar for the present study. These animals were randomly divided into 6 groups with 7 rats in each group. All groups of rats were kept under uniform husbandry condition in iron cages separately in groups. The processes of administration of these ingredients were continued for 36 weeks. The animals were sacrificed in six sittings with duration of 6 weeks between each sitting at 6th, 12th, 18th, 24th, 30th, & 36th week. Results: Kashmiri Namkeen Tea extract mixed with sodium chloride, and sodium bicarbonate caused premalignant changes in esophageal mucosa in the form of inflammation, Keratinsation, mucosal erosions, mucosal bleeding. These histopathological changes started to appear at 6th week and become more marked with further exposure in a duration dependent manner. Conclusion: Kashmiri Namkeen tea is carcinogenic; it produces premalignant changes in esophagus of Albino rats when exposure exceeds 6 weeks in a duration dependent manner.

Background: The present Randomized Controlled Trial (RCT) was conducted in the Postgraduate Department of Anatomy, Government Medical College Srinagar after taking ethical clearance from Institutional Ethical Committee. Materials and Methods: Fourteen albino rats weighing on an average 150 grams were taken from the animal house of Govt. Medical College Srinagar for the present study. These animals were randomly divided into 6 groups with 7 rats in each group. All groups of rats were kept under uniform husbandry condition in iron cages separately in groups. The processes of administration of these ingredients were continued for 36 weeks. The animals were sacrificed in six sittings with duration of 6 weeks between each sitting at 6th, 12th, 18th, 24th, 30th, & 36th week. Results: Kashmiri Namkeen Tea extract mixed with sodium chloride, and sodium bicarbonate caused premalignant changes in esophageal mucosa in the form of inflammation, Keratinsation, mucosal erosions, mucosal bleeding. These histopathological changes started to appear at 6th week and become more marked with further exposure in a duration dependent manner. Conclusion: Kashmiri Namkeen tea is carcinogenic; it produces premalignant changes in esophagus of Albino rats when exposure exceeds 6 weeks in a duration dependent manner.