This study ascertained the mediating effect of spiritual quotient on the relationship between emotional quotient and intelligence inventory of 315 persons deprived of liberty in General Santos City Jail. A stratified random sampling method using Slovin’s formula was used to determine the required sample number. A quantitative non-experimental research design using the descriptive-correlational technique was applied. Weighted mean, Pearson r, and path analysis were used to analyze the data. The results revealed that the emotional quotient of the respondents was high in self-awareness, self-control, empathy, motivation, and social competence while moderately high in self-confidence. The respondents' most common multiple intelligence was very high in terms of interpersonal, while high in terms of linguistic, logical-mathematical, spatial, bodily-kinesthetic, music, and intrapersonal. Moreover, the level of spiritual quotient was very high in spiritual awareness, while high in the existence of critical thinking and the discovery of personal meaning, and moderately high concerning consciousness development/development of awareness. Furthermore, there was a significant relationship between emotional quotient and intelligence inventory, emotional quotient and spiritual quotient, and spiritual quotient and intelligence inventory. Similarly, there was a direct effect of emotional quotient and intelligence inventory, emotional quotient and spiritual quotient, and spiritual quotient and multiple intelligence. Nevertheless, spiritual quotients aided the respondents by strengthening their multiple intelligences and connection to their emotional quotients.