Objective: This study evaluates the impact of structured patient education programs on compliance with home oxygen therapy and associated clinical outcomes in patients with chronic respiratory conditions. Methods: A randomized controlled trial was conducted with 50 patients using home oxygen therapy, randomly assigned to an intervention group (n=25) receiving a structured education program or a control group (n=25) receiving standard care. The education program included four one-hour sessions and weekly follow-up calls. Compliance rates, lung function (FEV1 and FVC), health-related quality of life (HRQoL), and hospitalizations were measured at baseline and after 6 months. Results: The intervention group showed significantly higher compliance rates (85.4% vs. 65.2%, p<0.01) and greater improvements in lung function (FEV1: +0.13 L vs. +0.02 L, p=0.03; FVC: +0.18 L vs. +0.01 L, p=0.02) compared to the control group. HRQoL scores improved more in the intervention group (SGRQ: -10.1 vs. -1.2, p<0.01; EQ-5D: +0.09 vs. +0.01, p=0.04). Additionally, the intervention group experienced fewer respiratory-related hospitalizations (0.8 vs. 1.6, p=0.04). Conclusion: Structured patient education programs significantly improve compliance with home oxygen therapy and lead to better clinical outcomes and quality of life for patients. These findings highlight the importance of integrating comprehensive education into the management of home oxygen therapy to enhance patient care.