Hydrogen is expected to play a key role in the Dutch energy strategy to decarbonize industries and provide balance to the renewable energy supply. Besides the national hydrogen transmission infrastructure from HyNetwork Services (HNS), hydrogen distribution grids will need to be developed to connect the HNS backbone with regional hydrogen supply and demand and to interconnect supply and demand nodes locally. Since distribution grids not only serve a large number of clients with different hydrogen pressure, purity, and volume requirements, but also can have numerous sources of hydrogen supply, the optimal grid configuration and characteristics are not immediately clear. This research provides general guidelines for future regional hydrogen grid development by reviewing the typologies of hydrogen customers that can be expected and then modelling an optimal hydrogen distribution grid that minimizes total societal costs. The results suggest that in order to meet the varying demands of potential hydrogen end-users in a distribution grid, the most optimal solution from a total system cost perspective is one involving multiple pressure and purity layers. However, under certain circumstances (e.g., a less concentrated network or more uniformity in pressure and purity demand requirements) the model chooses a simpler grid. Most importantly, grid operators must weigh the challenges associated with a complex multi-pressure layered network against the lower total system costs documented in this research when making infrastructure decisions to determine whether the most optimal configuration is still preferable when other practical considerations are taken into account.