Spin control represents an interesting avenue in modern electrochemistry with the ability to tune the state of reaction intermediates and the overall reaction selectivity and yield. One of the ways to achieve the reaction spin control is the preparation of specific electrodes, through the utilization of the so-called chiral-induced spin selectivity phenomenon (CISS). This approach is based on the utilization of chiral coatings on the surface of redox-active materials, which allows to align the spin of transited electrons, but limits the available current densities and overall electrode stability. In this work, we propose the realization of the CISS phenomenon with the implementation of intrinsically chiral 2D flakes of MoS2 doped with single Ni atoms. The created material was applied to an oxygen evolution reaction (OER) performed under alkaline conditions. The single atom catalyst provides the material redox activity, while the flakes chirality ensures the alignment of the spins of transited electrons. As a result, we reached significant enhancement of OER kinetic and suppressed hydrogen peroxide formation. Moreover, the utilization of intrinsically chiral materials with single atoms inclusion allows us to perform OER experiments at relatively large current density and significantly enhance the electrode stability in terms of both electrochemical activity and long-term suppression of hydrogen peroxide formation.