Background: Contaminated drinking water poses significant health risks to populations worldwide. In Yaoundé III District, Cameroon, access to clean drinking water is a pressing concern. This study aims to investigate the health risks associated with contaminated drinking water in this district. Methods: A cross-sectional study was conducted in Yaoundé III District. Water samples were collected from various sources and analyzed for microbiological and chemical contaminants. Health data were collected through surveys and medical records. Statistical analyses were performed to examine the relationship between water contamination and health outcomes. Results: The study found high levels of microbiological and chemical contaminants in drinking water sources. Significant associations were observed between water contamination and the prevalence of waterborne diseases, including diarrhea, typhoid fever, and cholera. Conclusion:The findings highlight the urgent need for interventions to improve water quality and reduce health risks in Yaoundé III District. Future research should focus on developing and implementing effective water treatment and management strategies.