Introduction: Cobalamin deficiency is a commonly faced issue now days with varying prevalence globally and different aetiological factors. Some of them may be easily correctable like consumption of cobalamin rich diet and avoidance of medications like Metformin and gastric acid lowering agents. This may lead to different clinical and haematological features with unexpected financial burdens. Aim: Our study was aimed to observe the effect of age and gender on cobalamin level and the effect of age, gender, and level of cobalamin on the three cell lines. Method: We selected a hundred patients after going through the inclusion and exclusion criteria. Their age, gender, serum cobalamin level and haemogram parameters were noted and correlated statistically. Result: Out of the hundred patients, we had 58 males, and 42 females and the maximum were in the age between 41 to 60 years (25%). Here, male patients and the elderly had more severe deficiency of cobalamin compared to their counterparts. We observed bi-cytopenia more commonly than isolated anaemia or pancytopenia. Out of the three variables (age, gender, and severity of cobalamin level) only male gender was statistically associated with cytopenia. Conclusion: We observed anaemia as the most common cytopenia in cobalamin deficiency and the severity of its deficiency was more in male gender and elderly people. There was no significant association between cobalamin deficiency and the type of cytopenia either in isolation or in combination. As we could see a high percentage of anaemia and bi-cytopenia in cobalamin deficient state, serum cobalamin should be assessed in all those with such cytopenias.

Introduction: Cobalamin deficiency is a commonly faced issue now days with varying prevalence globally and different aetiological factors. Some of them may be easily correctable like consumption of cobalamin rich diet and avoidance of medications like Metformin and gastric acid lowering agents. This may lead to different clinical and haematological features with unexpected financial burdens. Aim: Our study was aimed to observe the effect of age and gender on cobalamin level and the effect of age, gender, and level of cobalamin on the three cell lines. Method: We selected a hundred patients after going through the inclusion and exclusion criteria. Their age, gender, serum cobalamin level and haemogram parameters were noted and correlated statistically. Result: Out of the hundred patients, we had 58 males, and 42 females and the maximum were in the age between 41 to 60 years (25%). Here, male patients and the elderly had more severe deficiency of cobalamin compared to their counterparts. We observed bi-cytopenia more commonly than isolated anaemia or pancytopenia. Out of the three variables (age, gender, and severity of cobalamin level) only male gender was statistically associated with cytopenia. Conclusion: We observed anaemia as the most common cytopenia in cobalamin deficiency and the severity of its deficiency was more in male gender and elderly people. There was no significant association between cobalamin deficiency and the type of cytopenia either in isolation or in combination. As we could see a high percentage of anaemia and bi-cytopenia in cobalamin deficient state, serum cobalamin should be assessed in all those with such cytopenias.