Medicinal plants, containing bioactive compounds that offer therapeutic benefits, have been used across cultures for centuries to treat various health conditions. Historical records from ancient civilizations like the India, Egyptians, Greeks, and Chinese document their early medicinal use. Today, these plants remain vital in global healthcare, blending ancient wisdom with modern science to treat diseases and promote well-being, highlighting their enduring role in health and healing. Cucurbita moschata is highly valued for its dual role in both culinary and medicinal applications. Its elongated fruits are characterized by smooth skin and a sweet, nutty flavour making them popular in various dishes such as soups, stews, roasts and as a nutritious side dish. Rich in essential nutrients like vitamins A, C and E as well as dietary fibre and antioxidants including beta-carotene, it also supports immune health, aids in digestion and promotes heart health by lowering cholesterol levels. Medicinally, extracts derived from Cucurbita moschata such as cucurmosin, are known for their anti-inflammatory, antioxidant and potential anticancer properties contributing to overall wellness. This versatile plant is cultivated globally, contributing significantly to both culinary diversity and traditional health practices, offering a wide array of nutritional benefits and therapeutic uses. Keywords: Cucurbita moschata, cucurmosin, beta-carotene, antioxidant, anticancer