Introduction: Hereditary disorders of abnormal Hemoglobin variants are one of the commonest genetic disorders worldwide. Three broad groups of these disorders are: structural variants (hemoglobinopathies), thalassemias & hereditary persistence of fetal hemoglobin (HPFH). “β thalassaemia belt” where β thalassaemia more coomon include Mediterranean region, Africa, Middle East, some areas of India, Pakistan, and Southeast Asia. In India, average carrier rate for β thalassaemia is 3%. Objective: The objectives of this study are 1) to find out prevalence of various abnormal hemoglobin (Hb) variants by HPLC method in given period, 2) to compare hematological parameters among various abnormal hemoglobin variants. Materials and Methods: A Retrospective Study was conducted in a Laboratory in Tertiary care hospital at western-tribal part of India during July 2022 to August 2022. HbA, HbA2, HbF and other abnormal variants of hemoglobin were studied by HPLC (High Performance Liquid Chromatography). Hematological parameters tests were also done. Results: 2944 patients samples run in HPLC analyzer, and abnormal hemoglobin variants found in 160 cases. These 160 patients had abnormal Hb chromatogram on HPLC. β Thalassemia trait constituted 66 cases followed by 66 cases of HbS trait-heterozygous, 11 cases of HbS disease/anemia-homozygous , 6 cases of Compound HbS homozygous with β thalassemia trait, 6 cases of HbE trait-heterozygous, 3 cases of HbE disease-homozygous and 2 cases of HbD punjab. Conclusion: Various hereditary Hb disorders identified at Shree Vinoba Bhave Civil-Hospital, DNH (Dadra & Nagar Haveli-Union Territory) situated at western part of INDIA & this study reflectes problem magnitude, which may represent iceberg phenomenon. These hereditary Hb disorders are easily identified on HPLC platform via screening of antenatal women, school & college students. Policy makers, Health care department & various NGOs play important role in preventing these disorders via screening and education programmes.

Introduction: Hereditary disorders of abnormal Hemoglobin variants are one of the commonest genetic disorders worldwide. Three broad groups of these disorders are: structural variants (hemoglobinopathies), thalassemias & hereditary persistence of fetal hemoglobin (HPFH). “β thalassaemia belt” where β thalassaemia more coomon include Mediterranean region, Africa, Middle East, some areas of India, Pakistan, and Southeast Asia. In India, average carrier rate for β thalassaemia is 3%. Objective: The objectives of this study are 1) to find out prevalence of various abnormal hemoglobin (Hb) variants by HPLC method in given period, 2) to compare hematological parameters among various abnormal hemoglobin variants. Materials and Methods: A Retrospective Study was conducted in a Laboratory in Tertiary care hospital at western-tribal part of India during July 2022 to August 2022. HbA, HbA2, HbF and other abnormal variants of hemoglobin were studied by HPLC (High Performance Liquid Chromatography). Hematological parameters tests were also done. Results: 2944 patients samples run in HPLC analyzer, and abnormal hemoglobin variants found in 160 cases. These 160 patients had abnormal Hb chromatogram on HPLC. β Thalassemia trait constituted 66 cases followed by 66 cases of HbS trait-heterozygous, 11 cases of HbS disease/anemia-homozygous , 6 cases of Compound HbS homozygous with β thalassemia trait, 6 cases of HbE trait-heterozygous, 3 cases of HbE disease-homozygous and 2 cases of HbD punjab. Conclusion: Various hereditary Hb disorders identified at Shree Vinoba Bhave Civil-Hospital, DNH (Dadra & Nagar Haveli-Union Territory) situated at western part of INDIA & this study reflectes problem magnitude, which may represent iceberg phenomenon. These hereditary Hb disorders are easily identified on HPLC platform via screening of antenatal women, school & college students. Policy makers, Health care department & various NGOs play important role in preventing these disorders via screening and education programmes.