Endophytic fungi are abundant and have been found asymptomatically in most plants species. Endophytic fungi areconsidered as hidden members of the microbial world and represent an under-utilized resource of natural bioactivecompounds for agricultural, industrial and medicinal uses. As reported previously, several valuable natural products withanticancer, antimicrobial, and insecticidal properties have been successfully extracted from the endophytic fungi.Chemotherapy yields the first promise of destroying cancer cells that has distributed into the body. This is due to the factthat chemotherapeutic agents overlap with the process of dividing cancer cells, which in turn leads to establishing newcells. Vincristine (vinca alkaloids) and podophyllotoxin prohibit the microtubules polymerization at high drugconcentrations whereas Taxol™ and Taxotere stimulate the microtubules polymerization and stabilize the microtubules aswell at high concentrations. In This review, we critically attempt to summarize the mechanisms of the cancerchemotherapeutic drugs, namely, Taxol and Vincristine (vinca alkaloids) on the need for more the research in the field ofcancer chemotherapy.

Endophytic fungi are abundant and have been found asymptomatically in most plants species. Endophytic fungi areconsidered as hidden members of the microbial world and represent an under-utilized resource of natural bioactivecompounds for agricultural, industrial and medicinal uses. As reported previously, several valuable natural products withanticancer, antimicrobial, and insecticidal properties have been successfully extracted from the endophytic fungi.Chemotherapy yields the first promise of destroying cancer cells that has distributed into the body. This is due to the factthat chemotherapeutic agents overlap with the process of dividing cancer cells, which in turn leads to establishing newcells. Vincristine (vinca alkaloids) and podophyllotoxin prohibit the microtubules polymerization at high drugconcentrations whereas Taxol™ and Taxotere stimulate the microtubules polymerization and stabilize the microtubules aswell at high concentrations. In This review, we critically attempt to summarize the mechanisms of the cancerchemotherapeutic drugs, namely, Taxol and Vincristine (vinca alkaloids) on the need for more the research in the field ofcancer chemotherapy.