This report proposes an overview of a selected set of applications of digital fabrication technologies in craft processes, analyzing the implications and positive outcomes of a technology-mediated dialogue between new digital technologies and traditional know-how. In this document, FabLabs are presented as pivotal spaces for grassroot innovations, highlighting their consolidated role in supporting artisans toward innovative and sustainable productions. By merging the experience of the European laboratories and FabLab Venezia’s, a scorecard analysis has been conducted, analyzing the impact of digital technologies in social innovation-oriented and craft business models. This has led to the development of an operational toolkit for the implementation of digital fabrication processes in craft, specifically targeted to craft makers and artisans. This document constitutes the groundwork for the development of a methodology that merges technological tools, sustainability, and social responsibility, to train and support future-oriented innovative craft businesses.