The Global Flourishing Study (GFS) will involve data collection for some 240,000 participants, from twenty-two geographically and culturally diverse countries, with annual data collection on the same individuals for five years. The survey includes questions on well-being, along with demographic, social, economic, political, religious, personality, childhood, community, health, and character-based questions. The GFS will expand knowledge on the extent to which many of the world’s largest nations are or are not flourishing. The study has the capacity to advance our understanding of the societal determinants of human flourishing and to enrich our knowledge concerning how they vary by cultural context.