The first part of the research studies theoretical approaches, models and factors in determining the structural transformation of the world economy and presents some empirical assessments. The object of this study is trade and economic cooperation of the CIS countries in the context of structural transformation of the world economy and new trade and political restrictions introduced against Russia and Belarus, which have a significant impact on the entire system of foreign economic relations. The aim of the study is to assess the changes in the level of integration in different spheres of Russia, the EU, China with the CIS countries and CIS countries among themselves and the impact of sanctions against Russia and Belarus on the CIS countries. The relevance of the work is justified by the transformation of economic ties of the CIS countries, the forced need for Russia to search for new international transport and logistics routes and financial schemes and the processes of transformation of the system of international economic relations, which together form a new economic reality for the CIS. The paper uses an empirical method of quantitative data research, econometric method of calculating various indicators and indices, as well as systemic analysis. The main results of the study consist in analyzing changes in the conditions of trade and economic cooperation of post-Soviet countries and integration in different spheres in 2022, including interrupted projects, including those with third countries.