Human-computer interaction has a significant contribution in the designing and developing computer systems that have a diversity of different features and rationale in the world today. The designing of the right user-centred interface is a big challenge in systems development because a wrongly designed interface will result in resistance from different levels of users. On the other hand, the right user interface motivates the learners as well as the teachers to adopt the use of information system in learning and teaching. This study focuses on establishing how the human-computer interaction heightens the learning and teaching in schools; establishing the challenges facing learners and instructors of human-computer interaction, as well as investigate the influence of the user-centered approach in the adoption of information systems in learning and teaching and finally make a recommendation on the fundamentals for successful enactment of an information technology program in our schools.