This study aimed to enhance the competencies of Grade 12 learners in Physical Science, specifically on the topic of Polarity of Molecules, at Casambalangan National High School during the 2020-2021 school year. The participants included 28 Grade 12 Humanities and Social Sciences (HUMSS) learners, consisting of 11 males and 17 females. Learners were grouped into control and experimental groups using simple random sampling. The two-group Pretest-Posttest Experimental Research Design was employed, utilizing a teacher-made Pretest and Posttest that were quality assured by the subject coordinator and school head. The study's results revealed no significant difference between the control group’s pre-test and post-test scores, whereas a significant difference was observed for the experimental group. The intervention demonstrated a 'large effect size' on the academic scores of the learners, with a Cohen’s d value of 1.51, favoring the experimental group. This indicates that the Accessible, Interactive, Developed E-learning module (AIDE) effectively improved the competencies of Grade 12 learners in Physical Science, particularly in understanding the Polarity of Molecules. It is recommended that teachers across various disciplines strategically utilize the AIDE module for remedial instruction or supplemental activities to enhance student competencies.