The article the issue of diabetes (type 2) on preventive use of vegetal hypoglycemic agents is discussed. It represents the method of adoption of a natural hypoglycemic food supplement that provides high Bioavailability in the hypoglycemic substances used by the used plant nutrition (F. Myrtile, C. Phaseoli, R. Araliu, H. Eqisett, Fr. Rose, H. Hiperrici Fl. Chamomilla). The used products of diabetic purpose are described with the usage of this hypoglycemic supplement. In the supplementation the high bioavailability of substances of hypoglycemic activity is achieved by the extraction of water–borne substances, adding obtained extract on the active wheat bran and their lyophilic drying. The results of the prophylactic efficacy analysis of the supplement are presented on the example of laboratory animals (white rats). The advantage of hypoglycemic supplementation, which is developed by proposed method is proved in comparison with the usage of dry vegetable powders. Four groups of trial animals participated in the research. I — control, II, III and IV, which were artificially diseased with diabetes — with 0,1% of alcoholic solution of Dithizone. The II group was fed with a product containing a new additive, the III one with the same product without the additions, and the IV — with the same product plus the addition of the dry powder of the vegetable set.