Aims: The present study evaluates the antidiabetic activity of Piper Betle leaves extract on the blood glucose level of streptozotocin induced diabetic rat models. Objective: To study the antidiabetic activity of aqueous extract of Piper betle in streptozotocin induced diabetes in albino rats. ii) To compare the antidiabetic activity of Piper Betle extracts with that of standard drug glibenclamide used in the treatment of type 2 diabetes mellitus. Materials and Methods: In the present study 24 male albino wistar rats divided into 6 groups with 6 animals were taken. One group as control was given normal saline for 15 days daily. Other 3 groups were induced diabetes. Standard and test groups were fed with glibenclamide (0.5mg/kg) and aqueous extract (50, 100, 150mg/kg) daily for 15 days respectively caused a significant (P<0.01) reduction in blood glucose levels in diabetic rats. The body weight of diabetic animals was also improved after daily administration of extracts. The extract also improved other altered biochemical parameters associated with diabetes. Result: The results were analysed with student t-test.

Aims: The present study evaluates the antidiabetic activity of Piper Betle leaves extract on the blood glucose level of streptozotocin induced diabetic rat models. Objective: To study the antidiabetic activity of aqueous extract of Piper betle in streptozotocin induced diabetes in albino rats. ii) To compare the antidiabetic activity of Piper Betle extracts with that of standard drug glibenclamide used in the treatment of type 2 diabetes mellitus. Materials and Methods: In the present study 24 male albino wistar rats divided into 6 groups with 6 animals were taken. One group as control was given normal saline for 15 days daily. Other 3 groups were induced diabetes. Standard and test groups were fed with glibenclamide (0.5mg/kg) and aqueous extract (50, 100, 150mg/kg) daily for 15 days respectively caused a significant (P<0.01) reduction in blood glucose levels in diabetic rats. The body weight of diabetic animals was also improved after daily administration of extracts. The extract also improved other altered biochemical parameters associated with diabetes. Result: The results were analysed with student t-test.