Multiple sclerosis (MS), the most prevalent neurological disability, is an autoimmune mediated disorder that affects the central nervous system (CNS) and often leads to severe physical or cognitive incapacitation as well as neurological problems in young adults. Multifocal zones of inflammation due to focal T-lymphocytic and macrophage infiltrations, and oligodendrocyte death are the primary causes of myelin sheath de- struction that result in the formation of CNS plaques composed of inflammatory cells and their products, demyelinated and transected axons, and astrogliosis in both white and gray matter. Subtypes of MS are considered important not only for prognosis but also for treatment decisions and include: relapsing remitting MS (RRMS), primary progressive MS (PPMS), secondary progressive MS (SPMS), and progressive relapsing MS (PRMS). Induced symptoms include problems with walking, weakness, stiffness, and trouble with balance. lants have been used as medicines throughout history. Indeed, studies of wild animals show that they also instinctively eat certain plants to treat themselves for certain illnesses. Medicinal plants are widely and successfully used on every continent. In Asia, the practice of herbal medicine is extremely well established and documented. Multiple sclerosis is a chronic inflammatory disease that affects the brain and the spinal cord. Environmental factors such as vitamin D levels, viral infections, obesity, and smoking can contribute to MS development. Genetic factors also have a significant role in MS formation as several genes can increase susceptibility to this disease. The herbal plants showing strong activity on Multiple sclerosis in zingiberace family such as zingiber officinal and curcuma loga. Keywords: Multiple sclerosis, Zingiberace family, Astrocytes, Medicine, Animals