Lumpy virus cause the lumpy skin disease in live-stock animals like cattle and buffalo belong to Capri poxvirus genus and Poxviridae family, wide spread in across all country much damage the livestock sector in Pakistan reported in 2022. Cattle were more affected by lumpy virus than buffalo in Pakistan Transmission of lumpy virus mostly carry out via arthropods including as ticks and insects as well as toxic substances during blood feeding, has linear DNA in genome structure of 151 kb showed high stability against intense temperature. Lumpy virus affects badly to domestic animals including cattle and buffalo, mainly symptoms including appearance of lesion on skin, high fever and respiratory and digestive tract mucous membrane. ELISAs, real-time PCR and Indirect fluorescent antibody test effectively use in diagnosis of lumpy virus. This disease leads to huge economic losses such as abortion, reduction of milk and decline in infertility This review is also illustrating variety of vaccine recommended by authority to help full to minimize lumpy skin disease imposed by LSDV. There is no mostly effective treatment and vaccine available, only control and prevention encouragement in block and eradication of LSD.