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A medicinal herb as potential source of therapeutic aids has attained a significant role in health system. Genus Luffa belongs to Cucurbitaceae family is a tropical or sub tropical and warm climate fast growing plant. Luffa cylindrica as a medicinal plant has been widely employed in treatment of many diseases. It used as edible vegetable. The present paper is an attempt to provide a detailed taxonomy, phyto-chemical characters, medicinal and pharmacological potential of this valuable herb plant.