The purpose of this study is to survey if acetone O-(4 chlorophenylsulfonyl) oxime (1a) and acetone O-(2-naphtylsülphonyl)oxime (2a) compounds have antimicrobial and antioxidant properties or not. For this purpose, the antioxidant activity of the compounds was tested using the DPPH free radical method and the method of determining the antibacterial activity of newly synthesized compounds. As a result, compound 1a shows better antioxidant activity than compound 2a at all tested concentrations. The antibacterial activities of sulfonate derivatives on Staphylococcus aureus, Pseudomonas aeruginosa Escherichia coli, and Enterococcus hirae strains were investigated and it was determined that all compounds showed partial antibacterial activity for S. aureus, E. coli, and K. pneumoniae strains.