Over-The-Counter (OTC) drugs, or non-prescription drugs, are medicines available without a doctor's prescription for common health issues like pain, headaches, colds, and allergies. They are regulated by the FDA to ensure effectiveness and safety. This study aimed to evaluate the self-medication practice among Attahadi University Students. A cross-sectional study was conducted suing pre-validated questionnaire with 20 multiple-choice questions. It was distributed dace-to-face to university students during July 2023. Data was analyzed using descriptive statistics. In this study, it was revealed that many respondents were unaware of the advantages and disadvantages of using these medications, which could result in inappropriate use or potential injury. The most widely used class of OTC drugs were painkillers, and many students who took them complained of side effects. A sizable portion of participants mix various OTC medications to treat multiple ailments, which can be risky. Prioritizing safety and efficacy are key, and it is crucial to carefully study labels and seek professional advice as necessary.