The aim of the ROSiE Training Materials for Responsible Open Science is to learn how to practice open science (OS) responsibly and how to prevent research misconduct in the context of OS by providing necessary knowledge and developing specific skills and attitudes. The training material consists of a trainers' file including 8 units and respective activities, as well as materials for trainees – handouts and printouts and case collection. The activities can be implemented separately (e.g., for organising a single workshop to discuss cases) or for organising a complete two-day training course. Additionally, trainers can use the ROSiE online training course as a complementary resource to this training material. Students and researchers can use ROSiE online learning modules to implement self-directed learning. In this case, the trainee as a user of online ROSiE training materials takes the initiative, with or without the help of the trainer, determines his/her learning needs, formulates learning goals and evaluates learning outcomes. In this process, trainees are in charge of their learning, and they are autonomous in choosing what, how and where they are learning. Online training materials can also be used for the implementation of blended learning, which combines traditional on-site training led by a trainer with using online content to allow trainees to build their own learning experience. By blending face-to-face and online training methods, trainees can benefit from guidance and interaction with a trainer while having access to interactive and flexible training opportunities outside the classroom. Blended learning allows development of multimodal learning through visual, auditory, reading, discussion and writing methods. Multimodal learning expands inclusive learning opportunities.