This deliverable reports the work executed in H2020 SAbyNA Task 4.2. It evaluates the SbD methods collected in Deliverable4.1 on the basis of their potential usability in industry. Although important from a conceptual point of view, infact, the SbD methods described in D4.1 (available on Zenodo: 10.5281/zenodo.10818663) were not all suitable for industrial nano-manufacturing. To extract usable and accessible SbD methods from the whole list, Partners identified the factors that determine usability: clarity, accessibility, scalability, cost/benefits balance, retention of technical functions, number and types oflimitations. These factors were evaluated for each SbD methods, and this evaluation provided the basis for theirselection. Methods classified as “usable” covered a broad spectrum of practical cases. Partners identified at leastone usable SbD method for minimizing risk arising form the physicochemical drivers described in D4.1; notably,the list reported in this deliverable contains also SbD methods that target risk originating from release ofnanoparticles due to the properties of the supporting matrix. Selected methods covered most of the hazardousmechanisms that determine the toxicity of NF and NEP, and essentially all SbD approaches described in D4.1were described in at least one selected resource. For the usable methods, these deliverable reports usability cardsthat summarize the characteristics of the method, report the target physicochemical property, list potentiallimitation, and report the link to resource. These usability cards provide a useful tool for finding and accessingSbD resources.