Climate events in recent years have escalated to extreme levels. The traditional ways in which aquaculture is practiced must be reevaluated and focused towards sustainable production. Integrated aquaculture with algae has several advantages, which allow the reuse of scarce resources such as water, and space, in addition to the reuse of nutrients. The obtained biomass has not been used as a raw material of high biotechnological value. Currently, the technology to extract bioactive compounds, produce biodiesel, bioethanol, biofertilizers, and bioplastics, among others, is available. The aquaculture and biotechnology industries can complement each other successfully. Although there are challenges, global warming, water scarcity and future food demand are circumstances that force researchers, governments, and companies to take urgent measures.