Abstract: The conservation of palm-leaf manuscripts (Mss) in Oḍiśā, a state in eastern India, is a critical endeavour to safeguard an invaluable cultural and historical heritage. Palm-leaf manuscripts, known as "Tālapatra Granthas" in the local language, are ancient textual records written on dried and processed palm leaves. These manuscripts contain valuable knowledge in the domains of religion, literature, science, and various other subjects. This research paper aims to explore the challenges faced in the conservation of palm-leaf manuscripts in Oḍiśā and proposes effective strategies for their preservation. The study encompasses an in-depth examination of the factors contributing to the deterioration of palm-leaf manuscripts, including environmental conditions, biological threats, physical damage, and human interventions. Furthermore, the research investigates existing conservation practices and techniques employed in Oḍiśā and evaluate their effectiveness. It explores traditional methods of manuscript preservation, such as the use of natural oils and herbal treatments, as well as modern conservation approaches, including digitization and non-invasive imaging technologies. The paper also delves into the significance of palm-leaf manuscripts in Oḍiśā's cultural and historical context, emphasizing their role in preserving indigenous knowledge and intellectual traditions. It highlights the need for a comprehensive conservation plan that balances the preservation of the manuscripts' material integrity while ensuring wider accessibility for scholars, researchers, and the general public. Through a multidisciplinary approach, combining insights from conservation science, cultural heritage management, and archival studies, this research paper presents a framework for the sustainable conservation of palm-leaf manuscripts in Oḍiśā. It proposes recommendations for improved storage conditions, handling procedures, and conservation treatments, considering the unique characteristics of these manuscripts and their cultural significance. Ultimately, the findings of this research contribute to the broader discourse on manuscript conservation, providing practical insights and guidelines for preserving and promoting the rich legacy of palm-leaf manuscripts in Oḍiśā, thereby ensuring their transmission to future generations and fostering a deeper understanding of the region's cultural heritage. Key Words: Palm-leaf manuscripts, Conservation, Preservation, Tālapatra Granthas, Cultural heritage, Historical records, Physical damage, Traditional preservation methods, Digitization, Archival studies.