Objective To explore the current status of family environment and life satisfaction, and analyze the impact of family environment on life satisfaction among primary school students in the middle and upper grades. Method: Five hundred and six primary school students in the middle and upper grades were selected randomly from Guangdong Province, China. They were surveyed with Family Environment Scale-Chinese Version (FES-CV) and Life Satisfaction Scale for Adolescent (LSSA). Results: First, The total score of LSSA in this group was (184.71±29.98). Second, the result of multiple linear stepwise regression analysis showed that the scores of organization (ORN) and control (COL) positively predicted the total score of LSSA (β=0.168, 0.159, both P<0.01), and conflict (CON) negatively predicted the total score of LSSA (β=- 0.130, P<0.05). Conclusion: The life satisfaction of primary school students in the middle and upper grades is at a moderate level, and there is still a lot of room for improvement. Family environment may be one of the main influencing factors of life satisfaction among primary school students in the middle and upper grades.