This report documents Five Safes RO-Crate, a FAIR representation of software execution requests used by the TRE-FX architecture. A Five Safes RO-Crate represents a unit of computational access to sensitive information which is managed in accordance with a set of principles conforming to the 5 safe framework. The aim is to enable trusted workflow execution in a Trusted Research Environment (TRE), from an authenticated workflow run request, through approval and review processes to a completed workflow execution.