DataSHIELD provides a technological solution that can address many of the disclosure challenges in facilitating analysis by researchers and other health care professionals of individual level data. Although initially developed for work in the biomedical and social sciences, DataSHIELD can be used in any setting where microdata (data on individual subjects) must be analysed but cannot physically be shared with the research users. This report documents a TRE-FX implementation, which explored and integrated new analysis techniques (including DataSHIELD, which traditionally hasn’t been deployed in TREs) and interaction protocols without using the common components of the other two implementations, and instead implemented alternative components. This demonstrates the use of RO-Crates with different implementation choices and that the framework implementation can be modified and reconfigured.