This report outlines the progress that Georgia has made in operationalizing the One Health approach, while identifying continued needs for One Health system strengthening. The report is available in English and Georgian. Specific highlights of the report include: Overview of current One Health initiatives, national plans, policies, biosurveillance systems, and multi-sectoral coordination mechanisms; A country-specific risk profile that identifies key factors for infectious disease emergence, spread, vulnerability and mitigation; Case studies examining implementation successes and challenges at subnational and country levels; Key recommendations that synthesize findings on themes including One Health coordination, workforce and training, surveillance and monitoring of disease risks, laboratory systems, disease prevention and control, vulnerabilities, and financial resources. The report findings and overall approach provide a practical starting point for identifying systems-level coverage and needs to address threats to humans, animals and the environment in line with a One Health approach. We hope this report can be useful in guiding local implementation of the global One Health Joint Plan of Action and related investment priorities.