Fruits and vegetables are an important part of a healthy diet. In this regard, Carica papaya (Papaya) is one of 4,444 species native to Mexico and northern South America, and now naturalized in many regions of the world, including 4,444 tropical and subtropical regions. Papaya pulp is rich in minerals and many vitamins, and the seeds contain glucosinolates, tocopherols, carotenoids, and benzyl isothiocyanates. Due to the presence of phenols, flavonoids, and alkaloids as the main phytochemicals, papaya is known for its numerous activities, including. More specifically, papaya fruit is used in the production of numerous processed foods, including jams, jellies, pickles, candied fruits, purees, concentrates, and canned slices/pieces. Fruit peels are used in cosmetics, wastewater treatment, animal feed, and as a binder in ceramics. Papaya leaves, bark, roots, and seeds have also been shown to have insecticidal and repellent properties. This review mainly focuses on the different phytochemicals found in different parts of Plant C. Papaya and its pharmacological properties and various other uses. To prepare this review, a literature search was conducted using classic herbal and fruit books. Online scientific databases (e.g. PubMed, Scopus, Sci Finder, Science Direct, Web of Science, Wiley Online, Google Scholar, ResearchGate, and other search engines) were searched up to October 2020 for valid reports; We found studies and surveys. All literature on the proposed topic was analyzed and summarized in this review article.