In this paper, the development and benchmarking of a newly developed whole building hygrothermal model are presented. The model considers the building as a system and accounts for the dynamic heat, air and moisture (HAM) interaction between building envelope components and indoor environmental conditions including HVAC systems, moisture and heat sources. The methodology adapted in this work is to develop and validate two primary models: building envelope and indoor models independently and couple them to form the whole building hygrothermal model. After successful integration of the models, the whole building hygrothermal model is benchmarked against internationally published numerical and experimental test results. The holistic model is used to assess building enclosures durability, indoor conditions (temperature and relative humidity), occupant comfort, and energy efficiency of a building in an integrated manner.