The aquaculture industry is currently growing faster than other sectors of human protein production. However, every year, diseases inflict irreparable damage on this growing industry, which inevitably uses antibiotics. In the last two decades, vaccination as a preventive method against various bacterial pathogens in the aquatic industry Cultivation known and has reduced the use of antibiotics. Fish diseases can be caused by several factors, one of which is bacteria. Furunculosis, the most destructive bacterial disease of fish, is now almost distributed worldwide. Furunculosis is a debilitating and deadly disease that affects numerous species of breeding fishes.