Drug stability is a significant problem that affects drug quality. Freeze drying is one of the techniques that can be used to develop stable injectable-based drugs. This paper presents a new technique for developing regular injectable- based drugs by a freeze-drying process with the potential for various applica- tions in bioengineering and the pharmaceutical industry. This review aims to improve the current injectable systems from unstable to stable by freeze dry- ing technique. Injectable systems are dangerous, which leads to the degrada- tion of the drug. The freeze-drying process can be used for sound injectable systems. Characteristics of proteins and peptides are the primary concern of the pharmaceutical industry. Freeze drying provides a new, safe, and effec- tive way to preserve these substances without refrigeration or freezing. In the pharmaceutical industry, many efforts have been made to improve cur- rent protein formulations for injection. A new technique called freeze drying is emerging as a potential solution. This paper will explore the characteristics of freeze-drying and its possibilities for developing stable injectable drugs in more detail. Especially complex protein-based drugs present significant chal- lenges to manufacturers because their stability is low, and they often have harsh conditions that need to be stored - such as being kept frozen or cooled on ice at all times.