The capability of a proposed national launch system (NLS) to boost the personnel launch system (PLS) manned vehicle has been examined. A reference NLS configuration, the NLS-2 1.5 stage vehicle, and a reference HL-20 PLS configuration were used for the study. Performance has been analyzed for several PLS insertion orbits to support the Space Station Freedom resupply mission. The reliability of the NLS launch vehicle and its contribution to crew safety requirements have been determined. The launch-processing and launch facility requirements of these combined systems were also analyzed. Previous studies of these two systems have focused on either the PLS manned element or NLS launch vehicle. This paper combines the results of prior studies in an analysis of the integrated NLS/PLS configuration. This analysis has found the proposed NLS 1.5 stage launch vehicle to be an excellent booster for the PLS. Predicted performance margins for this launch-vehicle configuration are more than adequate, and acceptable reliability and safety levels are anticipated. Integration of this NLS/PLS configuration into NASA mixed-fleet launch architectures is feasible.