In recent years, research conducted in the US and in Italy has demonstrated production of radioisotopes in plasma focus devices, and particularly, on what could be termed "endogenous" production, to wit, production within the plasma it self, as opposed to irradiation of tar gets. This technique relies on the formation of localized small plasma zones characterized by very high densities and fairly high temperatures. The conditions prevailing in these zones lead to high nuclear reaction rates, as pointed out in previous work by several authors. Further investigation of the cross sections involved has proven necessary to model the phenomena involved. In this paper, the present status of research in this field is re viewed, both with regards to cross section models and to experimental production of radio isotopes. Possible out comes and further development are discussed.