Abstract Here we assess the route to convert low grade waste heat (<100°C) into electricity by leveraging the temperature dependency of redox potentials (Seebeck effect). We use fluid-based redox-active species, which can be easily heated and cooled using heat exchangers. By using a first principles approach, we designed a redox flow battery system with Fe(CN)63−/Fe(CN)64− and I−/I3− chemistry. We evaluate the continuous operation with one flow cell at high temperature and one at low temperature. We show that the most sensitive parameter, the Seebeck coefficient, can be controlled via the redox chemistry, the reaction quotient and solvent additives, and we present the highest Seebeck coefficient for this RFB chemistry. A power density of 0.6 W/m2 and stable operation for 2 hours are achieved experimentally. We predict high (close to Carnot) heat-to-power efficiencies if challenges in the heat recuperation and Ohmic resistance are overcome, and the Seebeck coefficient is further increased.