Malaysia Health Information Exchange (MyHiX) is part of Health Transformation System, which is a national agenda to improve the healthcare service using ICT as an enabler. Its main focus is to share patients’ discharge summary or clinical summary among healthcare facilities. This initiative was launched in November 2008. However, nine years after its launch, MyHiX has been successfully implemented only in eight healthcare institutions in Malaysia. Therefore, this paper presents a systematic review of the existing literatures related to Health Information Exchange or MyHiX, with the aim of exploring the empirical gaps and issues associated with its implementation. Six databases were used to locate relevant studies, namely IEEE, Proquest, Emerald, Science Direct, Google Scholar and Scopus. In total, 70 studies met the inclusion criteria. Further thematic analysis of these studies revealed that issues of MyHIX implementation could be categorized into technological, organizational, environmental and human contexts.