Two new species, Miconia galdamesiae and M. papillopetala are described from cloud forests of western Panama. Both species belong to a clade of Costa Rican and Panamanian taxa that typically have asymmetric leaf venation, flowers with calyces that are fused in bud but rupture into irregular lobes at anthesis, geniculate staminal filaments, five locular ovaries that are glandular-puberulent apically, exerted styles (herkogamous), and angulate seeds. The affinities of the new taxa are discussed and compared with presumed closest relatives and a comparative table is provided. Photographs of live plants and Scanning Electron Micrographs of foliar trichomes, flower buds, and whole flowers at anthesis are included for the new taxa as well as for Miconia brenesii and M. friedmaniorum, two closely related species that have been confused with the new taxa described here.